Dengue Duo

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Dengue Duo IgM & IgG Capture ELISA
E-DEN01D
Please note these products are not for sale or distribution in the United States and may not be available in all countries worldwide. Please contact Inverness Medical or your local Panbio distributor to determine availability.


Product Overview
The Panbio Dengue Duo IgM Capture & IgG Capture ELISA is for the qualitative detection of IgM and IgG antibodies to dengue virus in serum.

The Panbio Dengue Duo IgM Capture & IgG Capture ELISA offers an improvement over the HAI assay as an aid for the serological diagnosis of dengue infections between primary and secondary infection using a single dilution of serum, rather than a series of dilutions required for HAI assays.

The IgM cut-off is set to detect IgM levels characteristic of primary infection.

These ELISA tests are designed to distinguish between primary and secondary infections
This kit consists of the Dengue IgM Capture ELISA and the Dengue IgG Capture ELISA packaged together for convenience and cost savings
Ideal for use in regions where primary and secondary dengue are common
For the differentiation of primary and secondary dengue
Quick Info
Standardised method
Short incubation time (2 hr 10 min)
Break-apart wells
Ready-to-use colour coded reagents
Compatible with standard microplate technology
Reliable performance
Dengue IgM Capture and Dengue IgG Capture ELISA kits packaged together (192 tests)
Differentiates between primary and secondary infection
Performance
Dengue IgM Capture and Dengue IgG Capture ELISA serological sensitivity and specificity1
Serological sensitivity IgM 95% CI* IgG 95% CI*
Primary dengue
54/57 (94.7%)
85.4-98.91%
N/A
N/A
Secondary dengue2 64/115 (55.7%)3 46.6-64.7% 52/54 (96.3%) 73.8-93.6%
Serological specificity IgM 95% CI* IgG 95% CI
Negatives
83/83 (100%)
95.7 - 100 % 125/125 (100%) 97.1-100%
Primary dengue N/A 95.7 - 100 % 32/35 (91.4%) 76.9-98.2%
This data has been extracted from the Dengue IgM Capture and Dengue IgG Capture ELISA Instructions for Use.
Samples positive for secondary dengue infection by HAI (titre >= 2560)
The use of the Panbio Dengue IgG Capture ELISA (E-DEN02G) is recommended when secondary dengue is suspected
* Confidence Interval

Cross-reactivity data - Panbio Dengue IgM Capture ELISA1
Disease type Total specimens Positive (or equivocal) result
Epstein-Barr virus 10 0/10
Malaria 10 1/10
Influenza A 7 0/7
Influenza B 3 0/3
Anti-nuclear antibody 30 0/30
Rheumatoid factor 10 3/10
Hepatitis A 9 0/9
Leptospira 7 0/7
Salmonella typhi 9 0/9
Scrub typhus 10 0/10
West Nile virus 10 2/10
TOTAL 115 6/115
Cross-reactivity data - Panbio Dengue IgG Capture ELISA2
Disease type Total specimens Positive (or equivocal) result
West Nile virus 10 0/10
Malaria 10 0/10
Scrub typhus 7 0/7
Leptospira 12 2/12
Hepatitis A 6 0/6
Rheumatoid factor 10 0/10
Anti-nuclear antibody 10 1/10
TOTAL 65 3/65
Publications
Cuzzubbo, A., et al. (1997). Commercial Assays for the Serological Diagnosis of Dengue Infection. Arbovirus Research in Australia. 7:56-60. Queensland Institute of Medical Research.

Cuzzubbo, A., et al (1998) Detection of Specific Antibodies in Saliva during Dengue Infection. Journal of Clinical Microbiology Dec. 1998:3737-3739

Cuzzubbo, A., et al. (1999) Comparison of PanBio Dengue Duo Enzyme-Linked Immunosorbent
Assay (ELISA) and MRL Dengue Fever Virus Immunoglobulin M Capture ELISA for Diagnosis of Dengue Virus Infections in Southeast Asia. Clinical and Diagnostic Laboratory Immunology Sep. 1999:705-712

Porter, K., et al (1999) Evaluation of a Commercially Available Immunoglobulin M Capture Enzyme-Linked Immunosorbent Assay Kit for Diagnosing Acute Dengue Infections. Clinical and Diagnostic Laboratory Immunology Sep. 1999:741-744

Sang, C., et al (1998) Evaluation of a Commercial Capture Enzyme-Linked Immunosorbent Assay for Detection of Immunoglobulin M and G Antibodies Produced during Dengue Infection. Clinical and Diagnostic Laboratory Immunology Jan. 1998: 7-10

Vaughn, D., et al (1999) RAPID SEROLOGIC DIAGNOSIS OF DENGUE VIRUS INFECTION USING A COMMERCIAL CAPTURE ELISA THAT DISTINGUISHES PRIMARY AND SECONDARY INFECTIONS. Am. J. Trop. Med. Hyg. 60(4): 693-698

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