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Through ADME studies, NoAb BioDiscoveries helps clients identify leads.

  • Cell permeability assays
  • MDR1-MDCK Substrate/inhibition Studies
  • BCRP Substrate/Inhibition Studies
  • Brain Free Fraction Determination
  • In Cerebro™ In Vitro RBEC Permeability
  • Plasma protein binding
  • Metabolic stability in hepatocytes
  • Metabolic stability in liver subcellular fractions
  • Cytochrome P450 induction studies
  • Cytochrome P450 enzyme subtype inhibition studies
  • Time-Dependent CYP Inhibition Studies
  • Plasma stability assays
  • Cytotoxicity assays
  • Customer specific screening assays (radiochemical, fluorescent, etc.)