DTEx™ Gene Expression Analysis is available using a custom selection of genes on our DTEx™ microarray. DTEx™ Gene List

We can also validate DTEx™ results, or evaluate any client selected genes using QPCR.

In a typical experiment, investigators can choose to supply total RNA for DTEx™ gene expression analysis or they can select to have NoAb prepare, treat, and extract total RNA from a selection of cells, cell lines, or tissues. Samples are processed using the DTEx™ microarray, and a Summary Data Report consisting of normalized data, color matrix plots, hierarchical cluster plots, and fold induction tables is provided. Drug effects on selected genes can also be confirmed by QPCR.

Sample Data

Below is a comparison of the fold change in Cytochrome P450 gene expression levels in primary human hepatocytes treated with prototypical inducers and unknown compounds.

• 1. Compound X is similar to Rifampicin in its ability to induce CYP3A4 gene expression.
• 2. Compound Y is similar to Phenobarbital in its ability to induce CYP2C8 gene expression.
• 3. Compound Z is similar to 3-methyl-cholanthrene in its ability to induce CYP1A2 gene expression.