Pharmacokinetics or PK is the study of what the body does to a drug when administered externally to a living organism and is divided into a number of areas including studying the extent of absorption, distribution, metabolism and excretion (ADME) of a pharmaceutical compound. Preclinical PK studies are important in drug discovery research so as to generate data for the construction of PK profiles. New drug candidates in drug discovery research should be selected based on the exhibition of appropriate PK profiles because these compounds should achieve the desired pharmacological action with minimal side effects. One of the primary reasons cited for the failure of lead compounds during clinical trials is the lack of a suitable PK profile. For cutting edge preclinical PK studies that will help you identify lead compounds suitable for further preclinical and clinical development, choose NoAb BioDiscoveries (www.noabbiodiscoveries.com).
NoAb BioDiscoveries is a leading organization that helps shape and optimize drug discovery research by delivering a wide range of specialized and proprietary research services that are focused on lead selection and optimization. These services can be found at www.noabbiodiscoveries.com and include preclinical PK studies done in vivo, in vitro ADME assays, bioanalytical services and gene expression assays. These services are high quality and highly efficient due to the innovative tools and technologies developed by NoAb BioDiscoveries to provide services that achieve success and accelerate the timelines associated with the drug discovery process. Advanced research tools allow preclinical PK studies to be performed that better characterize the PK properties of new drug candidates, optimizing the selection of viable clinical candidates. At NoAb BioDiscoveries, clients are afforded the ability to profile compounds to select the best candidates for further preclinical and clinical development.
Preclinical PK studies at NoAb BioDiscoveries are carried out in-house under strict guidelines by highly trained and experienced scientists ensuring quality, efficiency and timeliness. The scientists skillfully design and perform the best strategies and protocols for any drug discovery needs and carry out both specialized and standard protocols according to customer specifications. The preclinical PK studies are carried out on fully conscious animals that are appropriately cannulated for drug administration and sample collection. Studies for preclinical PK properties at NoAb BioDiscoveries are performed on carotid artery and jugular vein catheterized rats with intra-duodenal dosing, carotid artery, jugular vein and bile duct catheterized rats and guinea pigs and hepatoportal vein catheterized rats. In addition to these standard protocols, scientists at NoAb BioDiscoveries have used their knowledge and experience to develop specialized preclinical PK techniques such as serial collection of plasma and cerebrospinal fluid (CSF) from freely moving rats and microdialysis for studies on the concentrations of drugs that penetrate the central nervous system (CNS). Details of all the in vivo PK studies performed at the research facility are available at www.noabbiodiscoveries.com.
Through the provision of superior scientific procedures such as the preclinical PK studies and DTExâ"¢ micro-array technology, this CRO delivers accurate and reliable results that help clients select the best candidates for further development ensuring their success. NoAb BioDiscoveries is committed to accelerating the drug discovery process so that you can enjoy reduced costs and time to identify new drug candidates and maximize success in a very competitive market. Choose drug discovery services from NoAb BioDiscoveries and become a frontrunner in the pharmaceutical development business!
